Top 5 Takeaways Cluster of Cases: Five children in Clark County, Nevada, were hospitalized with acute liver failure after consuming “Re2al Alkalized Water.” Broader Impact: Eighteen probable and four suspected

Top 5 Takeaways Higher Incidence in Unvaccinated: Unvaccinated individuals had a significantly higher incidence of SARS-CoV-2 infection (30.1 per 1,000) compared to fully vaccinated individuals (8.7 per 1,000). Increased Risk

Top 5 Takeaways Implementation of Digital Notification: North Carolina implemented an automated digital notification system on December 24, 2020, to notify COVID-19 positive patients via text and email. Increased Notification

Top 5 Takeaways High Prevalence of SCD Among Caregivers: Approximately 12.6% of unpaid caregivers aged ≥45 years reported subjective cognitive decline (SCD), compared to 10.2% of noncaregivers. Health and Demographic

Top 5 Takeaways Increase in Synthetic Opioid Overdose Deaths: Overdose deaths involving synthetic opioids, primarily illicitly manufactured fentanyl, have increased approximately tenfold since 2013 and accelerated during the COVID-19 pandemic.

Top 5 Takeaways Increased Risk: Pregnant and recently pregnant women are at higher risk for severe illness and death from COVID-19 compared to non-pregnant women. COVID-19–Associated Deaths: Mississippi reported 15