Top 5 Takeaways Initial Case Identification: The outbreak was first identified when a 33-year-old male experiencing homelessness was hospitalized with severe symptoms including bilateral ptosis, extremity weakness, and respiratory failure.

Top 5 Takeaways Increased Anxiety and Depression: Nationally, anxiety and depression severity scores increased significantly from August to December 2020, peaking in December 2020–January 2021. Subsequent Decrease: Both anxiety and

Top 5 Takeaways Vaccine Effectiveness: COVID-19 mRNA vaccines provided significant protection against hospitalization in adults with previous SARS-CoV-2 infection, with effectiveness higher after a booster dose. Omicron vs. Delta: Vaccine