Top 5 Takeaways Mask Use Reduces Transmission: Close contacts with any unmasked exposure had significantly higher odds of receiving a positive SARS-CoV-2 test result compared to those with only masked

Top 5 Takeaways Lower Vaccination Coverage in Rural Areas: COVID-19 vaccination coverage with the first dose was significantly lower in rural counties (58.5%) compared to urban counties (75.4%). Increased Disparities

Top 5 Takeaways Full FDA Approval: On January 31, 2022, the FDA granted full approval to the Moderna COVID-19 vaccine for individuals aged ≥18 years. ACIP Recommendation: On February 4,

Top 5 Takeaways Vaccine Effectiveness Decline: The overall age-adjusted vaccine effectiveness (VE) against new COVID-19 cases declined from 91.8% to 75.0% during May 3–July 25, 2021. Stable Hospitalization Protection: VE