Top 5 Takeaways

  1. JYNNEOS Vaccine Distribution: Over 931,000 JYNNEOS vaccine doses were administered in the U.S. from May 22 to October 10, 2022, as part of the monkeypox outbreak response.
  2. Demographic Disparities: Initially, there were disparities in vaccination rates among racial and ethnic groups. However, these disparities decreased over time, with increased vaccination among Black and Hispanic communities.
  3. Vaccination Completion Rates: Approximately 57.6% of those eligible for a second dose received it. Completion rates were highest among older adults, non-Hispanic White individuals, and residents of the Southern U.S.
  4. Challenges in Vaccine Administration: Limitations in vaccine supply and distribution, as well as difficulties in linking first and second doses across jurisdictions, posed challenges in ensuring optimal vaccination coverage.
  5. Public Health Implications: Addressing disparities and improving equitable access to vaccination are crucial for controlling the monkeypox outbreak and protecting at-risk populations.


This MMWR Article was created prior to the conventional renaming of Monkeypox to its more standard and appropriate name, Mpox. To avoid confusion, Monkeypox is retained when writing this article, but all future works should use Mpox.

Original Article Author and Citation

Corresponding Author

Jennifer L. Kriss,

Suggested Citation

Kriss JL, Boersma PM, Martin E, et al. Receipt of First and Second Doses of JYNNEOS Vaccine for Prevention of Monkeypox — United States, May 22–October 10, 2022. MMWR Morb Mortal Wkly Rep 2022;71:1374–1378. DOI:


This MMWR article reports on the administration of the JYNNEOS vaccine, used to prevent monkeypox, in the United States between May 22 and October 10, 2022. A total of 931,155 doses were administered, with a focus on individuals with known or presumed exposure to monkeypox or those at high occupational risk.


The study analyzed vaccination data reported to the CDC, focusing on the distribution of first and second doses, demographics of vaccine recipients, and variations in vaccination rates across different regions and populations.


The study highlighted progress in vaccine distribution, especially in increasing vaccination among Black and Hispanic populations. However, it also noted challenges such as supply limitations, logistical issues, and disparities in vaccine access and uptake.


The report underscores the importance of tracking and addressing vaccination disparities to reduce health inequities. Ensuring equitable access and acceptance of the vaccine is essential for optimal protection against monkeypox and controlling the outbreak.


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