Top 5 Takeaways New Vaccine Option: JYNNEOS, a replication-deficient Vaccinia virus vaccine licensed in 2019, is now recommended by ACIP for preexposure prophylaxis against orthopoxviruses, offering an alternative to ACAM2000.

Top 5 Takeaways Significant Testing Capacity and Results: The Laboratory Response Network (LRN) tested 2,009 specimens for monkeypox, identifying 730 (36.3%) positive cases from 395 patients, with 159 confirmed by

Top 5 Takeaways Enhanced Risk for Persons with HIV: Persons with advanced HIV infection, especially those not virologically suppressed with antiretroviral therapy (ART), may face increased risk for severe monkeypox

Top 5 Takeaways Disproportionate Impact on Specific Populations: 99% of monkeypox cases occurred in men, with 94% reporting male-to-male sexual or close intimate contact. Racial and ethnic minority groups, particularly

Top 5 Takeaways High Rate of Contamination: In a study, 70% of sampled household objects and surfaces in a home of two monkeypox patients tested positive for monkeypox virus DNA

Top 5 Takeaways Significant Impact of One-Time Partnerships: Despite accounting for less than 3% of total daily partnerships, one-time sexual partnerships are responsible for approximately 50% of daily Monkeypox virus

Top 5 Takeaways Behavioral Changes Among MSM: Approximately half of the men surveyed reported reducing their number of sex partners, one-time sexual encounters, and use of dating apps to prevent

Top 5 Takeaways Identification of False-Positive Results: The report highlights three cases of false-positive Orthopoxvirus PCR test results in individuals with atypical rashes and no epidemiologic link to monkeypox, emphasizing

  Top 5 Takeaways High Prevalence of HIV and STIs: Among 1,969 monkeypox cases in eight U.S. jurisdictions, 38% had HIV, and 41% had a diagnosed STI in the past